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SGAs, in general, lead to a higher risk of adverse events than nonpharmacological treatment options. Nevertheless, for most comparisons, the overall findings indicated no statistically significant differences in benefits but a lower risk of adverse events for nonpharmacological treatment options.
For risk of harms, we graded the strength of evidence as moderate for some outcomes of three comparisons—namely, SGAs compared with CBT, acupuncture, and St. Such shared and informed decisionmaking might enhance treatment adherence and improve treatment outcomes for patients with MDD, especially because treatment continuity is one of the main challenges in treating such patients.
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