Stomach rumble

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   20.05.2018  5 Comments

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This review is the first to compile the available evidence on the efficacy of the various pharmacological treatments for IBS on the basis of IBS subtype and specific symptoms. The low baseline abundance of mtDNA molecules may predispose smooth muscle cells of the muscularis propria external layer to the toxic effects of thymidine and deoxyuridine, and exposure to high circulating levels of nucleosides may account for the mtDNA depletion observed in the small vessel wall. Intestinal villi help to absorb nutrients from food, but when gluten is consumed, the immune system attacks these villi as a result.


The literature search identified 58 placebo-controlled trials of the efficacy of medications for treating IBS symptoms, which were critically evaluated and reported. We also observed mitochondrial proliferation and mtDNA depletion in small vessel endothelial and smooth muscle cells.



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5 thoughts on “Borborgymi

  1. Chronic intestinal pseudo-obstruction CIPO is a highly morbid and often life-threatening condition characterized by marked dysfunction of gut propulsive motility, which results in a clinical picture mimicking mechanical obstruction.

  2. Treatment of irritable bowel syndrome. CIPO is an important cause of chronic intestinal failure, because affected individuals become unable to maintain normal nutrition and body weight.

  3. The available studies suggest improvement in various IBS symptoms with loperamide, fibre supplements, lubiprostone, tricyclic antidepressants TCAs , selective serotonin receptor inhibitors SSRIs , antispasmotics, rifaximin, pregabalin, gabapentin, clonidine, octreotide and probiotic treatments.

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